Klion

Drug name: Klion

Other names used:

Apo-Metronidazole®
Fragyl®
Metromidol®
Neo-Tric®

Active Ingredients:

Metronidazole

Therapeutic actions: Bactericidal: inhibits DNA synthesis in specific (obligate) anaerobes, causing cell death; antiprotozoal-trichomonacidal, amebicidal: biochemical mechanism of action is not known.

Indications: Acute infection with susceptible anaerobic bacteria

Acute intestinal amebiasis
Amebic liver abscess
Trichomoniasis (acute and partners of patients with acute infection)
Preoperative, intraoperative, postoperative prophylaxis for patients undergoing colorectal surgery
Topical application in the treatment of inflammatory papules, pustules, and erythema of rosacea
Unlabeled uses: prophylaxis for patients undergoing gynecologic, abdominal surgery; hepatic encephalopathy; Crohn's disease; antibiotic-associated pseudomembranous colitis; treatment of Gardnerella vaginalis, giardiasis (use recommended by the CDC)

Contraindications and cautions: Contraindicated with hypersensitivity to metronidazole; pregnancy (do not use for trichomoniasis in first trimester).

- Use cautiously with CNS diseases, hepatic disease, candidiasis (moniliasis), blood dyscrasias, lactation.

Adverse effects:

CNS: Headache, dizziness, ataxia, vertigo, incoordination, insomnia, seizures, peripheral neuropathy, fatigue
GI: Unpleasant metallic taste, anorexia, nausea, vomiting, diarrhea, GI upset, cramps
GU: Dysuria, incontinence, darkening of the urine
Local: Thrombophlebitis (IV); redness, burning, dryness, and skin irritation (topical)
Other: Severe, disulfiram-like interaction with alcohol, candidiasis (superinfection)

Interactions:

Decreased effectiveness with barbiturates
Disulfiram-like reaction (flushing, tachycardia, nausea, vomiting) with alcohol
Psychosis if taken with disulfiram
Increased bleeding tendencies with oral anticoagulants

Additional Information: DO NOT SHARE THIS MEDICINE with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.