Klion
Drug name: Klion
Other names used:
- Apo-Metronidazole®
- Fragyl®
- Metromidol®
- Neo-Tric®
Active Ingredients:
Metronidazole
Therapeutic actions: Bactericidal: inhibits DNA synthesis in specific (obligate) anaerobes, causing cell death; antiprotozoal-trichomonacidal, amebicidal: biochemical mechanism of action is not known.
Indications: Acute infection with susceptible anaerobic bacteria
- Acute intestinal amebiasis
- Amebic liver abscess
- Trichomoniasis (acute and partners of patients with acute infection)
- Preoperative, intraoperative, postoperative prophylaxis for patients undergoing colorectal surgery
- Topical application in the treatment of inflammatory papules, pustules, and erythema of rosacea
- Unlabeled uses: prophylaxis for patients undergoing gynecologic, abdominal surgery; hepatic encephalopathy; Crohn's disease; antibiotic-associated pseudomembranous colitis; treatment of Gardnerella vaginalis, giardiasis (use recommended by the CDC)
Contraindications and cautions: Contraindicated with hypersensitivity to metronidazole; pregnancy (do not use for trichomoniasis in first trimester).
- Use cautiously with CNS diseases, hepatic disease, candidiasis (moniliasis), blood dyscrasias, lactation.
Adverse effects:
- CNS: Headache, dizziness, ataxia, vertigo, incoordination, insomnia, seizures, peripheral neuropathy, fatigue
- GI: Unpleasant metallic taste, anorexia, nausea, vomiting, diarrhea, GI upset, cramps
- GU: Dysuria, incontinence, darkening of the urine
- Local: Thrombophlebitis (IV); redness, burning, dryness, and skin irritation (topical)
- Other: Severe, disulfiram-like interaction with alcohol, candidiasis (superinfection)
Interactions:
- Decreased effectiveness with barbiturates
- Disulfiram-like reaction (flushing, tachycardia, nausea, vomiting) with alcohol
- Psychosis if taken with disulfiram
- Increased bleeding tendencies with oral anticoagulants
Additional Information: DO NOT SHARE THIS MEDICINE with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.
