Zanocin
Drug name: Zanocin
Other names used:
- Oflocet®
- Oflocin®
- Tabrin®
- Tarivid®
Active Ingredients:
ofloxacine
Therapeutic actions: Ofloxacin is an antibiotic that is used to treat skin and bone infections, sexually transmitted diseases, urinary tract and prostate infections, and respiratory and gastrointestinal infections. Ofloxacin acts by severely injuring the cell walls of the infecting bacteria, thereby preventing them from growing and multiplying. This medication kills susceptible bacteria, but it is not effective against viruses, parasites, or fungi.
Indications: Ofloxacin is indicated for the treatment of the following bacterial infections if these are due to ofloxacin-sensitive pathogens:
- Lower respiratory tract infections caused by Haemophilus influenzae, Haemophilus parainfluenzae, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis and Pseudomonas aeruginosa.
- Infections of the urinary tract.
- Sexually transmitted diseases; Acute uncomplicated urethral and cervical gonorrhoea, urethritis and cervicitis due to Chlamydia trachomatis. Mixed infections of the urethra and cervix due to Chlamydia trachomatis and Neisseria gonorrhoea.
Contraindications and cautions: Hypersensitivity to ofloxacin or related chemotherapeutic agents of the quinolone-derivative group.
Ofloxacin should not be administered to pregnant or lactating women.
Ofloxacin should not be administered to patients with cerebral convulsive disorders.
DOSAGE AND DIRECTIONS FOR USE
Ofloxacin tablets should be swallowed with a little liquid. It may be taken on an empty stomach or with meals. The dosage should be determined according to the sensitivity of the causative organism and the severity of the infection.
The following dosages are recommended:
Pyelonephritis: 200 mg twice daily for 5-7 days.
Infections of the lower respiratory tract: 400 mg twice daily for 7-10 days. The daily dose may be altered depending on the severity of the infection.
Uncomplicated urethral and cervical gonorrhoea: A single dose of 400 mg
Urethritis and cervicitis due to chlamydia trachomatis: 600 mg daily in divided doses for up to 7 days.
For patients with impaired renal function and elderly patients the dosage of ofloxacin should be adjusted according to the degree of impairment. With a creatinine clearance of less than 30 mL to 10 mL/min, an oral single dose should be administered every 24 hours, e.g. 200 mg once daily. With a creatinine clearance of less than 10 mL/min, the normal single dose should be given initially. This dose should then be reduced to half and administered every 24 hours, e.g. 200 mg initially, thereafter 100 mg once daily.
Adverse effects:
allergic manifestations may occur, in particular hypersensitivity reactions of the skin. Skin reactions on exposure to strong sunlight have been reported.
Could be distinguished the following side effects
Minor: Abdominal pain, diarrhea, dizziness, insomnia, light-headedness, nausea, or vomiting. These side effects should disappear as your body adjusts to the drug.
Major: Tell your doctor about any side effects that are persistent or particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about agitation; confusion; headache; irregular heartbeat; joint pain; restlessness; severe diarrhea (which may be watery or contain blood or pus); skin rash, itching, or redness; or swelling of the lower leg. If your symptoms of infection seem to be getting worse rather than improving, contact your doctor.
Interactions: Ofloxacin interacts with several other types of medications:
- Probenecid can increase the concentrations of this drug in the blood.
- Ofloxacin may increase the effects of theophylline or oral anticoagulants. Closer monitoring of the effects of these medications is recommended.
- Avoid using quinidine, procainamide, amiodarone, and sotalol because of the increased risk of side effects when used with ofloxacin.
- Antacids, iron, magnesium, sucralfate, zinc, and didanosine may decrease the absorption of ofloxacin. Thus, ofloxacin should be taken at least two hours before or two hours after a dose of any of those medications.
- BE SURE TO TELL YOUR DOCTOR about any medications you are currently taking, especially any of the medications listed above.
Additional Information: DO NOT SHARE THIS MEDICINE with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.
