Ospamox

Drug name: Ospamox

Other names used:

Sinacilin®
Tolodina®
Trimox®
Zerrsox®
Zimox®

Active Ingredients: Amoxicillin

Therapeutic actions: Amoxicillin is an aminobenzyl penicillin that has a bactericidal action due to its inhibition of the synthesis of the bacterial cell wall. It exerts a bactericidal effect against many Gram-positive and Gram-negative microorganisms. Amoxicillin is not effective against beta-lactamase producing organisms.

Indications: Ospamox is used in the treatment of:

Upper respiratory tract infections;
Genito-urinary tract infections;
Skin and soft tissue infections;
Lower respiratory tract infections;
Prophylaxis of Endocarditis - Dental Procedures;
Urethritis (due to Neisseria gonorrhoeae);
Lower urinary tract infections;

Contraindications and cautions: Amoxicillin is a penicillin and should not be given to patients with a history of hypersensitivity to beta-lactam antibiotics (eg. penicillins, cephalosporins).

Adverse effects: Side-effects, as with other penicillins, are uncommon and mainly of a mild and transitory nature. The majority of the side-effects listed below are not unique to amoxicillin and may occur when using other penicillins.

Common side effects:

Gastric complaints, nausea, loss of appetite, flatulence, soft stools, diarrhoea, enanthemas (particularly in the region of the mouth), dry mouth, taste disturbances. These effects on the gastrointestinal system are mostly mild and frequently disappear either during the treatment or very soon after completion of therapy. The occurrence of these side effects can generally be reduced by taking amoxicillin during meals;
Skin rash;

Uncommon side effects:

Prolonged and repeated use of the preparation can result in superinfections and colonisation with resistant organisms or yeasts such as oral and vaginal candidiasis;
Vomiting;
Cutaneous reactions such as exanthema, pruritus, urticaria; the typical morbilliform exanthema occurs 5 to 11 days after commencement of therapy. The immediate appearance of urticaria indicates an allergic reaction to amoxicillin and therapy should therefore be discontinued.

Rare side effects:

Eosinophilia;
Mucocutaneous candidiasis and antibiotic associated colitis including pseudomembranous colitis and haemorrhagic colitis. If severe and persistent diarrhoea occurs, the very rare possibility of pseudomembranous colitis should be considered. The administration of anti-peristaltic agents is contraindicated;
Superficial tooth discolouration has been reported in children taking the oral suspensions. Good oral hygiene may help to prevent tooth discolouration as it can usually be removed by brushing;
Drug fever has been reported.

Very rarely may appear the following adverse effects:

Reversible leucopenia (including severe neutropenia or agranulocytosis), reversible thrombocytopenia and haemolytic anaemia. Prolongation of bleeding time and prothrombin time;
As with other antibiotics, severe allergic reactions, including angioneurotic oedema, anaphylaxis, serum sickness and allergic vasculitis. If a hypersensitivity reaction is reported, the treatment must be discontinued;
Development of a black tongue;
Hepatitis and cholestatic jaundice. Moderate and transient increase of liver enzymes. The significance of a rise in liver enzymes is unclear;
Skin reactions such as erythema multiforme exudativum, Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous and exfoliative dermatitis and acute generalised exanthematous pustulosis;
Interstitial nephritis, crystalluria;
Hyperkinesia, dizziness and convulsions. Convulsions may occur in patients with impaired renal function or in those receiving high doses.

Interactions: Before taking amoxicillin, tell your doctor if you are using any of the following drugs:

methotrexate (Rheumatrex, Trexall);
probenecid (Benemid);
a sulfa drug (such as Bactrim or Septra);
an antibiotic such as azithromycin (Zithromax), clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), telithromycin (Ketek), or troleandomycin (Tao);
a tetracycline antibiotic such as demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

If you are using any of these drugs, you may not be able to use amoxicillin, or you may need dosage adjustments or special tests during treatment.
There may be other drugs not listed that can affect amoxicillin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Additional Information: DO NOT SHARE THIS MEDICINE with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.