Plavogrel

Drug name: Plavogrel

Other names used:

• Plavix®

Active Ingredients:

• clopidogrel

Therapeutic actions:  Plavogrel is an inhibitor of thrombocyte aggregation. It works by selectively inhibiting the binding of ADP to thrombocyte receptors and activating of GPIIb/IIIa complex, thus suppressing thrombocyte aggregation. The drug does not affect the activity of phosphodiesterase. Clopidogrel's effect is not irreversible thus the affected thrombocytes become dysfunctional. The restoration of normal thrombocyte function thus takes 7 days after the use of the drug.

Indications: The preparation is indicated in treatment of:

• Prophylaxis of ischemic disorders in patients with atherosclerosis:
• Myocardial infraction
• Blood-stroke
• Abrupt vascular death

Contraindications and cautions: The preparation should not be used in cases of:

• Acute bleeding including peptic ulcer and intracranial hemorrhage
• Hypersensitivity to the components of the preparation

Plavogrel should be used with caution in:

• Increased risk of possible trauma
• Possible surgery
• Homeostasis disorders
• Severe liver dysfunction

Adverse effects: There are possible side-effects associated with this medicine that can affect individuals in different ways. If a side effect is stated here, that does not necessarily mean the fact that all people using Plavogrel will experience it or any other. The side-effects include:

• Blood-coagulation system: gastrointestinal bleeding, rarely – hemorrhagic stroke
• Haemopoietic system: neutropenia, thrombocytopenia
• Gastrointestinal tract: diarrhea, abdominal pain, dyspepsia, gastritis, constipation, peptic ulcer
• Dermatological reactions: skin rash

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with Clopidogrel, please read the information provided with Plavogrel or consult your doctor or pharmacist. The side effects include:

Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with  Plavogrel. Similarly, check with your doctor or pharmacist before taking any new medication while taking this one, to ensure that the combination is safe.  Especially mention the following drugs and groups of drugs:

• NSAID's
• Antiepileptics
• Blood thinners
• Other antiaggregants
• Neuroleptics
• Heparin

Additional Information: DO NOT SHARE  Clopidogrel with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.