Agen
Drug name: Agen
Active Ingredients:
- Amlodipine besilate
Therapeutic actions: Agen contains the active ingredient amlodipine. Amlodipine belongs to a group of medicines called calcium channels blockers. Amlodipine exerts antianginal and hypotensive action due to blocking calcium channels and, thus, lowers the transmembrane entrance of calcium ions into the vascular tissue.
Antianginal action is associated with dilating of coronary and peripheral arteries and arteriols. Amlodipine relieves the symptoms of angina due to relaxing of peripheral arteriols, reducing peripheral resistance, lowering cardiac preload and oxygen demand of the heart tissue.
Amlodipine exerts the dose dependent hypotensive effects. Hypotensive action arises from direct vasodilating affect on the smooth muscles of the vessels. Amlodipine reduces the myocardial hypertrophy of the left ventricle, exerts anti-atherosclerotic and cardioprotective action in coronary heart disease. Amdlodipine does not affect contractility and conductibility of myocardium and doesn’t cause the reflective increase in heart rate.
Indications: Agen is used in the following conditions:
- High blood pressure (hypertension)
- Angina pectoris
- Prinzmetal's angina
Contraindications and cautions: Agen should not be used in the following conditions: Hypersensitivity to amlodipine or dihydropiridine.
- Arterial stenosis
- Hypertrophic cardiomyopathy
- Arterial hypotension
- Vasculogenic shock
- Collapse
- Tachycardia(increased heart rate)
- Cardiogenic shock
- In the first month after acute heart attack
- People younger 18 years of age
- Pregnancy
- Breastfeeding
Agen should be used with caution before during or right after pregnancy. Consult your doctor on possible contradictions during that periods.
Necessarily inform your doctor if you experience the following conditions:
- Liver disorders
- Sick sinus syndrome
- Disorders of the lipids’ metabolism
- Elderly age
Warning!
- Grapefruit juice may reduce the blood levels of Agen.
- Regularly control your body weight and dental health while taking Agen(amlodipine)
- You should take Agen(amlodipine) regularly for it to be effective. It may take several weeks before you experience the full benefit of amlodipine, and you should continue using it even if you are feeling better.
Adverse effects: There are possible side-effects associated with this medicine that can affect individuals in different ways. If a side effect is stated here, that does not necessarily mean the fact that all people using Agen will experience it or any other.
- More common side effects include: Fatigue, flushing, dizziness, fluid retention and swelling, migraine.
- Less common side effects include: nausea, sleepiness, abdominal pain.
The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with Agen, please read the information provided with Agen or consult your doctor or pharmacist.
Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with Agen. Similarly, check with your doctor or pharmacist before taking any new medication while taking this one, to ensure that the combination is safe.
Agen may interact with the following drugs:
- Potassium-sparing diuretics(Spironolactone)
- Allopurnol, cytostatics, immunologic depressants, glucocorticoids, procainamide
- Other hypertensive medicines: water pills, ACE inhibitors, Beta-blockers, calcium channel blockers and others.
- NSAID's
- Alcohol
- Estrogens
- Antipsychotic
- Lithium preparations
- Narcotic substances, anesthetics
- Alpha-adrenostimulants
- Procainamide
- Chinidine
Additional Information: DO NOT SHARE Agen with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.
