Anaprilin

Drug name: Anaprilin

Other names used:

• Avlocardyl®
• Dociton®
• Inderal®
• Inderal LA®
• Inderalici®
• InnoPran XL®
• Propranolol Hydrochloride Intensol®
• Sumial®

Active Ingredients: Propranolol

Therapeutic actions: Propranolol is part of a class of drugs called beta-adrenergic blocking agents, or beta blockers for short. As the name implies, beta blockers block beta receptors in the body. Beta receptors are located in a number of places within the body, including the heart and blood vessels. These receptors are what stress hormones (such as adrenaline) attach to and cause certain reactions in the body, such as an increase in:

• Heart rate
• The force with which the heart pumps blood
• Blood pressure (both systolic blood pressure and diastolic blood pressure).

By blocking beta receptors, propranolol causes the reverse effect of stress hormones. It decreases heart rate and both systolic and diastolic blood pressures, as well as the heart's workload. This means that the heart requires less blood and oxygen to work properly.
For people with migraines or an essential tremor, it is not known exactly how propranolol works. However, there are beta receptors in the brain that may be involved.

Indications: Some uses of propranolol include:

• Controlling high blood pressure (hypertension)
• Relief of angina symptoms
• Treatment following a heart attack to improve survival
• Treatment for atrial fibrillation
• Migraine prevention
• Decreasing the severity of tremors in people with familial or essential tremor
• Improving symptoms in people with hypertrophic subaortic stenosis, a condition in which the middle part of the heart thickens
• Controlling pheochromocytoma symptoms.

However, Propranolol does not cure these diseases.
Propranolol may also be recommended for other reasons, such as anxiety treatment. Propranolol has not been approved for use in children.

Contraindications and cautions: You should not take propranolol if you:

• Are allergic to propranolol, or any inactive component used to make propranolol. Your healthcare provider or pharmacist has a list of inactive ingredients.
• Have a slow heartbeat (bradycardia) with a certain type of irregular heart rhythm (specifically, second or third degree heart block).
• Have asthma.

You should talk with your healthcare provider prior to taking propranolol hydrochloride if you have:

• Heart disease, including congestive heart failure, a history of heart attack, or irregular heart rhythm
• Wolff-Parkinson-White syndrome
• A slow heart rate
• Asthma
• Bronchitis
• Chronic obstructive pulmonary disease (COPD)
• Emphysema
• Kidney disease
• Liver disease, including cirrhosis
• Diabetes
• Depression
• Pheochromocytoma
• Psoriasis
• Glaucoma
• Hyperthyroidism
• Raynaud's phenomenon or other circulation problems
• A blood vessel disease
• Any allergies, including allergies to other beta blockers, foods, dyes, or preservatives.

Also, let your healthcare provider know if you:

• Are pregnant or trying to become pregnant
• Are breastfeeding
• Smoke
• Drink alcohol
• Will be undergoing surgery or anesthesia.

Adverse effects: Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Propranolol may cause side effects.

• dizziness or lightheadedness
• difficulty sleeping
• excessive tiredness
• upset stomach
• vomiting
• rash
• diarrhea
• constipation

If you experience any of the following symptoms, call your doctor immediately:

• difficulty breathing
• sore throat
• unusual bleeding
• swelling of the feet or hands
• unusual weight gain
• chest pain
• slow, irregular heartbeat

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
Especially pay attention to the following drugs:

• Amiodarone (Cordarone®)
• Cimetidine (Tagamet®)
• Fluoxetine (Prozac®)
• Paroxetine (Paxil®, Paxil® CR™, Pexeva™)
• Quinidine
• Ritonavir (Norvir®)
• Imipramine (Tofranil®)
• Ciprofloxacin (Cipro®, Cipro XR®)
• Fluvoxamine (Luvox®)
• Isoniazid (INH™)
• Theophylline (Elixophyllin®, Theo-24®, Uniphyl®, TheoCap™, Theochron®)
• Zileuton (Zyflo®)
• Zolmitriptan (Zomig®)
• Rizatriptan (Maxalt®)
• Fluconazole (Diflucan®)
• Tolbutamide (Orinase®)
• Rifampin (Rifadin®, Rimactane®, Rofact®)
• Alcohol
• Phenytoin (Dilantin®, Phenytek™)
• Phenobarbital (Solfoton®)
• Cigarette smoking
• Propafenone (Rythmol®)
• Lidocaine (Xylocaine®)
• Diazepam (Valium®)
• Aluminum hydroxide gel (Amphojel®)
• Cholestyramine (Prevalite®, Questran®, Questran Light®, LoCholest®)
• Colestipol (Colestid®)
• Warfarin (Coumadin®, Jantoven®)
• Disopyramide (Norpace®)
• Digoxin (Digitek®, Lanoxicaps®, Lanoxin®).

drug interactions with propranolol can also occur with calcium channel blockers, such as:

• Amlodipine (Norvasc®)
• Verapamil (Calan®, Isoptin®)
• Verapamil Extended-Release (Calan® SR, Covera-HS®, Isoptin® SR, Verelan® Verelan® PM)
• Diltiazem (Cardizem®)
• Diltiazem ER (Cardizem® CD, Cardizem® LA, Cardizem® SR, Dilacor XR®, Diltia XT®, Tiazac®)
• Nifedipine (Adalat®, Procardia®)
• Nifedipine ER (Adalat® CC, Procardia XL®)
• Felodipine (Plendil®)
• Nisoldipine (Sular®)
• Isradipine (DynaCirc®)
• Nicardipine (Cardene®).

Angiotensin-converting enzyme inhibitors (ACE inhibitors) can also interact with propranolol. Examples of ACE inhibitors include:

• Quinapril (Accupril®)
• Benazepril (Lotensin®)
• Enalapril (Vasotec®)
• Ramipril (Altace®)
• Fosinopril (Monopril®)
• Captopril (Capoten®)
• Lisinopril (Prinivil®, Zestril®)
• Trandolapril (Mavik®).

Additional drug interactions with propranolol include:

• Alpha blockers for high blood pressure or benign prostatic hyperplasia (BPH), such as doxazosin (Cardura®), prazosin (Minipress®), terazosin (Hytrin®), tamsulosin (Flomax®), and alfuzosin (Uroxatral®)
• Reserpine
• Clonidine (Catapres®, Duraclon®)
• Epinephrine (EpiPen®)
• Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Motrin®, Advil®), naproxen (Naprosyn®), naproxen sodium (Aleve®, Anaprox®, Naprelan®), diclofenac (Cataflam®, Voltaren®), indomethacin (Indocin®), nabumetone (Relafen®), oxaprozin (Daypro®), celecoxib (Celebrex®), meloxicam (Mobic®), etodolac (Lodine®), ketoprofen, ketorolac (Toradol®), and others
• Tricyclic antidepressants, such as amitriptyline (Elavil®), doxepin (Sinequan®), imipramine (Tofranil®), and nortriptyline (Pamelor®)
• Monoamine oxidase inhibitors (MAOIs), such as isocarboxazid (Marplan®), phenelzine (Nardil®), selegiline (Eldepryl®, EMSAM®), and tranylcypromine (Parnate®)
• Haloperidol (Haldol®)
• Thyroid medicines, such as Synthroid®
• Certain Diabetes medicines, such as glyburide (Diabeta®, Glynase™, Micronase®).

Additional Information: DO NOT SHARE THIS MEDICINE with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.