Plecidrex

Drug name: Plecidrex

Other names used:

• Adlefane®

Active Ingredients:

• dihydralazine
• hydrochlorothiazide
• reserpine

Therapeutic actions: Plecidrex is a combined preparation which consists of 3 ingredients: reserpin – sympatholitic, dihydralazine sulfate – arterial vasodilatator, hydrochlorothiazide – diuretic. The overall effect which is reached is decrease in blood pressure.

Indications: The drug is indicated in treatment of arterial hypertension.

Contraindications and cautions: The drug should not be used in the following conditions:

• Depression
• Parkinson's disease
• Epilepsy
• Electroshock therapy
• Stomach and duodenal ulcer in acute phase
• Ulcerous colitis
• Pheochromocytoma
• Subsidiary MAO inhibitor treatment
• Systemic lupus erythematosus
• Expressed tachycardia and cardiac insufficiency
• Cardiac insufficiency as a result of mechanical blockage
• Isolated right ventricular insufficiency due to lung hypertension
• Anuria, severe renal insufficiency
• Renal insufficiency
• Refractory hypoglycemia, hyponatriaemia, hypercalciumemia
• Hyperuricimia
• Pregnancy
• Hypersensitivity to any components of the preparation.

If signs of depression occur stop the treatment immediately. Patients with liver dysfunction need to be monitored during treatment.

Adverse effects: There are possible side-effects associated with this medicine that can affect individuals in different ways. If a side effect is stated here, that does not necessarily mean the fact that all people using Plecidrex will experience it or any other. The side-effects include:

• Gastrointestinal tract: diarrhea, dry mouth, increased gastric juice secretion, increased salivation, dyspeptic conditions, nausea, vomiting, increased appetite, ulcer formation, constipation, diarrhea, gastrointestinal bleeding.
• Cardiovascular system: sinus bradycardia, swelling, ortostatic hypotension, increased facial blood flow, fainting, cardiac insufficiency, changes in brain blood flow, tachycardia, increased heart rate, hypotension, angina.
• Respiratory system: swelling of the nasal cavity, labored breathing, nasal bleeding.
• CNS and peripheral nervous system: headache, dizziness, depression, irritability, nightmares, increased tiredness, extrapyramidal dysfunction, anxiety, decreased concentration, abnormal orientation, brain swelling, agitation, anorexia, irritability, peripheral neuritis, paresthesia, sleep disturbance.
• Urogenital system: decreased sexual function, impotence, changes in libido dysuria, glomerulonephritis.
• Endocrine system: changed body weight, increased secretion of prolactin, galactorrhea,swelling of the mammary glands
• Organoleptical changes: vision impairment, conjunctiva hyperemia, delacrimation, decreased hearing.
• Liver side-effects: jaundice, hepatitis, cholestasis, pancreatitis
• Haemopoietic system: anemia, leukopenia, thrombocytopenia, agranulocitosis, hemolitic anemia, oppression of haemopoietic function
• Changes in electrolyte balance: hypokalemia, increased levels of lipids in blood, hyponatriaemia, hypomagnemia, hyperuricimia, hypercalciumemia, hyperglycemia, glucoseuria, severe metabolic dysfunction in diabetes,
• Dermatological reactions: skin rash, photosensitivity, necrotic vasculitis, lupus erythematosus a like syndrome, toxic epidermal necrolysis, eczema, itching.
• Other: flu like symptoms, weakness, anemia, purpura.

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with Plecidrex, please read the information provided with Plecidrex or consult your doctor or pharmacist.

Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with Plecidrex. Similarly, check with your doctor or pharmacist before taking any new medication while taking this one, to ensure that the combination is safe. Especially mention the following:

• Other anti-hypertensive drugs
• Mao inhibitors
• Alcohol
• Tricyclic antidepressants
• Antiarrhythmic drugs
• Sympatomimetics
• Neuroleptics
• Miorelaxants
• NSAID's
• Antimycotic
• Gastric ulcer treatment (carbenoxalone)
• Antiviral drugs
• Vitamin D and calcium preparations
• Cephalosporin antibiotics
• Hormones (glucocorticoids)
• Diabetes treatment (insulin dose correction)

Additional Information: DO NOT SHARE Plecidrex with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.