Warfarin

Drug name: Warfarin

Other names used:

• Coumadin®
• Jantoven®
• Marevan®
• Waran®

Active Ingredients:

• Warfarin

Therapeutic actions: Warfarin belongs to indirect action anticoagulants(blood-thinners), Warfarin works by inhibiting the production of vitamin-K dependent blood-coagulation factors((II, VII, IX and X) and proteins C and S in the liver. Warfarin doesn't act on the formed clots, but prevents their growth and formation of new clots(thrombs).

Indications: Warfarin is used in the following conditions:

• Thrombembolia of the lungs
• Thrombosis of the deep veins
• Atrial fibrillation
• Heart attack(myocordial infarction)
• In prosthesis of the cardiac valves

Contraindications and cautions: Warfarin should not be used if any of the following conditions apply to you:

• Bleeding or danger of bleeding development in some severe diseases
• Bacterial endocarditis
• Severe liver failure
• Obstructive jaundice
• Severe
• Disseminated intravascular coagulation
• Deficiency of C and S proteins
• Bleeding diathesis
• Low platelet count
• Stomach and duodenal ulcers in aggravation phase
• Stroke
• Chronic alcoholism
• Severe
• Recent surgical interventions
• Children
• Pregnancy
• Known hypersensitivity to warfarin

Blood-thinners increases the risk of bleedings. During the treatment regularly control your blood coagulation system. Tell your doctor if you experienced digestive system disorders while the treatment with warfarin.

Adverse effects: There are possible side-effects associated with this medicine that can affect individuals in different ways. If a side effect is stated here, that does not necessarily mean the fact that all people using Warfarin will experience it or any other.

• Blood-coagulation system: bleedings
• Cardiovascular system: in rare cases disorders of the circulation in extremities and internals
• Digestive system: nausea, vomiting, diarrhea, stomach pain, liver dysfunction
• reactions:hives, itching, dermatitis.
• Others: fever, weakness, alopecia.

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with Warfarin, please read the information provided with Warfarin or consult your doctor or pharmacist.

Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with Warfarin. Similarly, check with your doctor or pharmacist before taking any new medication while taking this one, to ensure that the combination is safe.

Allopurinol, amiodarone, anabolic steroids ,heparin, glibenclamide, glucagon, levamisole, clarithromycin, diazoline, disulfiram, danazol, diazoxide, disopyramide, isoniaside, ketoconazole, clofibrate, metronidazole, miconazole, nalidixic acid, nilutamid, chinine, tamoxifen, thyroxin, chinine, chinidine, fluconazole, chloramphenicole, cimetidine, laxatives, dipiridamole ethanol may enhance the effects of Warfarin.

Warfarin may interact with:

• (azithromycin, erythromycin, tetracycline, cephalosorins);
• Non-steroidal agents (Acetylsalicylic acid [ASA], celecoxib); acetaminophen;
• (fluoxetine, paroxetine, sertraline);
• Stomach ulcer / acid reducing agents (cimetidine, omeprazole, ranitidine);
• Lipid lowering agents (fibrates, statins such as lovastatin and simvastatin);

Diuretics, barbiturates, K, glutetimid, griseofulvin, dicloxacillin, carbamazepine, mianserin, retinoid, rifampicin, sucralfate, phenazone, colestiramin impair the effects of Warfarin. Smoking impair the effects of Warfarin.

Additional Information: DO NOT SHARE Warfarin with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.