No-Spa
Drug name: NO-SPA
Active Ingredients:
- Drotaverine hydrochloride
Therapeutic actions: Drotaverine hydrochloride is an isoquinoline spasmolytic. Drotaverine exerts antispasmodic action on the smooth muscle due to inhibiting the activity of the enzyme called phosphodiesterase IV and, thus, increasing the concentration of adenosine cyclic phosphate(cyclo-AMP). Cyclo-AMP inactivates myosin-light-chain kinase resulting in relaxation of the smooth muscle.
Drotaverine lowers the tonicity of the smooth muscles of the internals, reduces their motion activity and moderately dilates blood vessels. Drotaverine does not act on CNS and vegetative nervous system.
Indications: Nospa is used for profilaxis and treatment of
- Spasm of the smooth muscles (renal,gastric and intestinal colic, biliary and gall-bladder dyskinesia, cholecystitis, postcholecystectomy syndrome)
- Spasm related to pielitis, proctitis, tenesmus, pylorospasm, gastroduodenitis, gastric and duodenal ulcer, nephrolithiasis
- Spasm of the peripheral, cerebral and coronary arteries.
NOSPA can also be indicated in algodismenorrhea, threat of miscarriage, premature birth, spasm of uteruses pharynx during birth, protracted opening of uteruses pharynx, post-natal contractions.
Contraindications and cautions: You should not use Nospa if any of the following conditions apply to you:
- Allergy or hypersensitivity to drotaverine hydrochloride or other components used to make No-spa
- Liver and kidney failure
- Heart failure
- 2nd and 3rd AV-blockage
- Cardiogenic shock
- Arterial hypotension
NO-SPA should be used with caution in people with atherosclerosis of the coronary arteries, adenoma of the prostate gland, glaucoma, pregnancy and lactation.
Adverse effects: There are possible side-effects associated with this medicine that can affect individuals in different ways. If a side effect is stated here, that does not necessarily mean the fact that all people using No-spa will experience it or any other.
The most common side effects include: headache, increased heart rate, hypotension, hot flash, sweatiness, skin allergic reactions(rash and itching).
The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with No-spa, please read the information provided with Nospa or consult your doctor or pharmacist.
Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with No-spa. Similarly, check with your doctor or pharmacist before taking any new medication while taking this one, to ensure that the combination is safe.
- NO-SPA impairs the therapeutic effect of Levodopa.
- NO-SPA enhances the action of papaverine, bendazole and other spasmolytics
- No-spa enhanes hypotension caused by tricyclic antidepressants, chinidine and procainamide.
- No-spa reduces the spasmogenic activity of morphine
- Phenobarbital increases the manifestation of the spasmolytic action of Drotaverine.
Additional Information: DO NOT SHARE No-spa with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.
