Skinoren

Drug name: Skinoren


Other names used:

• Azelex®
• Emerox®
• Finevin®
• Skinoderm®

Active Ingredients: azelaic acid

Therapeutic actions: The antimicrobial property of azelaic acid and a direct influence on follicular hyperkeratosis are assumed to be the basis for the therapeutic efficacy of Skinoren Acne Cream in acne.
Azelaic acid exerts an antibacterial effect on Propionibacterium acnes and causes a significant reduction of the colonisation density of Propionibacterium acnes. A significant reduction of the fraction of free fatty acids in the skin surface lipids also occurs.
In animal experiments azelaic acid inhibits the proliferation of cultivated keratinocytes (suppression of DNA synthesis) and accelerates the comedolysis of tetradecane-induced comedones. After treatment with Skinoren Acne Cream ultrastructural changes in particular of the keratohyaline granules and of filaggrin, an important factor in keratinisation occurred. These findings suggest that, under clinical conditions, Skinoren Acne Cream affects the keratinocytes and the pattern of keratinisation.
The amount of azelaic acid recovered in the viable epidermis and the corium increased with the time of exposure and was approximately 9,5% of the applied dose after 24 hours. Following topical application of 1 g azelaic acid (5 g Skinoren Acne Cream) to human volunteers 2,2% (+ 0,7%) of the dose was excreted as unchanged substance in the urine within 72 hours.

Indications: Topical treatment of mild to moderate acne vulgaris.

Contraindications and cautions: Hypersensitivity to Skinoren Acne Cream (propylene glycol). Safety in pregnancy and lactation has not been established.

Adverse effects: The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Skinoren Acne Cream lacks the potential for bleaching hair and clothes. Local skin irritation (eg reddening or scaling, itching and burning) may occur, usually at the start of treatment, but it usually regresses in the course of treatment. Photosensitivity reactions have been reported. Care must be taken that Skinoren Acne Cream does not come into contact with the eyes. If it does, the eyes should immediately be thoroughly rinsed with copious amounts of water.
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

Interactions: There are no significant interactions reported with this medicine.

Additional Information: DO NOT SHARE THIS MEDICINE with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.