Indotroxin
Drug name: Indotroxin
Other names used:
- Indovenol®
Active Ingredients:
Indomethacin Troxerutine
Therapeutic actions: Indotroxin is a combined drug for topical application, which combines the potent topical antiphlogistic action of indometacin and the capillarotonic and venotonic effect of troxevasin. The proper gel vehicle contributed to the direct impact, with pronounced antiedemic, pain-relieving, cooling and antithrombotic effect. Indometacin inhibits the prostaglandine synthesis and decreases the level of mediators containing with inflammatory reactions. This provokes increased resorption of infiltration changes observed after inflammation processes. Furthermore, it has a marked analgesic effect, elevating the excitation threshold to pain stimulation at the level of the thalamus. Troxevasin has a pronounced venotonic, capillarotonic, antiphlogistic and haemostatic action and possesses a series of effects, manifested to various degrees, antiallergic effects as well. It reduces the permeability and fragility of the capillaries and prevents the damage of the basal membrane of endothelial cells by various noxae and restricts the thrombotic processes in initial stages. The preparation has a good skin tolerance and has no sensibilizing effect.
Indications:
- Diseases of joints and muscles (bursitis, tendovaginitis, synovitis, myositis, etc.),
- in case of varicose syndrome with pain and edemas,
- haemorrhoids,
- traumatic haematomas,
- postimmobilization states etc.
Contraindications and cautions:
- hypersensitivity to the active substances or to any of the ingredients of Indovasin gel;
- hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs).
Special precautions for use:
- Indotroxin gel is applied only on intact (unimpaired) skin. Avoid contact of
- Indotroxin gel with mucous membranes, open wounds, or eyes.
- Laboratory monitoring of WBC and platelet count is necessary with
- treatment duration exceeding 10 days.
- Drug interactions and other forms of interactions
- No concomitant administration with corticosteroids is recommended due to
- higher risk of ulcer formation.
WARNINGS IN SPECIFIC GROUPS OF PATIENTS
- No application is recommended to children below 14 years due to lack of
- sufficient clinical experience.
- No application of Indotroxin gel is recommended to persons with
- hypersensitivity to foods and drugs, bronchial asthma, allergic rhinitis, or
- predisposition to other allergic reactions.
Pregnancy and breast-feeding
- No clinical experience exists to prove the safety of Indotroxin gel during pregnancy and breast-feeding. In such cases, Indotoxin gel may be applied only if the anticipated benefit exceeds the risk.
- Effects on the ability to drive and use machines:
- Indotroxin gel has no effect on the ability to drive and use machines.
- Data about the other ingredients
- Indotroxin gel contains sodium benzoate and propylene glycol, which may have an irritating effect on the skin.
Adverse effects: Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Skin irritation reactions: erythema, itching, skin rashes are reported very rarely following Indotroxin gel application. They disappear rapidly following discontinuation of the treatment.
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
Additional Information: DO NOT SHARE THIS MEDICINE with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.
