Zitazonium

Drug name: Zitazonium

Other names used:

• Nolvadex®

Active Ingredients:

• Tamoxifen

Therapeutic actions: Zitazonium contains the active ingredient tamoxifen that belongs to a part of preparations called selective estrogen receptor modulators (SERMs). Tamoxifen exerts both estrogenic and anti-estrogenic effects. Tamoxifen exerts estrogenic action on the skeletal tissue and anti-estrogenic action on the breast. Mechanism of anti-estrogenic action is associated with competitive binding with estrogen receptors in target prgans and prevents their interaction with endogenic ligand 17-b-estradiol. Tamoxifen retards the progression of neoplastic process stimulated by estrogens.

Indications: Tamoxifen is approved to treat the following conditions:

• Cancer of the mammary gland in women in post-menopausal period
• Endometrial cancer
• Anovulatory sterility
• Cancer of the prostate gland in resistance to other medication
• Melanoma that contains estrogenic receptors

Contraindications and cautions: You should not use Tamoxifen if any of these conditions apply to you:

• Known hypersensitivity or allergy to any of the medication ingredients
• Unexplained vaginal bleeding
• Pregnancy
• Breastfeeding

Let your doctor know if you have

• a history of blood clots or stroke
• high calcium blood levels
• non-cancerous uterine or ovarian problems
• cataracts

Regularly control blood pressure while the treatment with Tamoxifen

Adverse effects: There are possible side effects associated with this medicine that can affect individuals in different ways. If a side effect is stated here, that does not necessarily mean the fact that all people using Tamoxifen will experience it or any other.

• Digestive system: anorexia, nausea, vomiting
• CNS: depression, dizziness, tiredness
• Vision organs: cataract and retinopathy
• Hematopoietic system: leukopenia, thrombocytopenia
• Allergic reactions: exanthem
• Other: fever, moderate metrorrhagia, thromboembolia, thrombophlebitis, edema, high calcium blood levels, pain in bones

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with Tamoxifen, please read the information provided with Tamoxifen or consult your doctor or pharmacist.

Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with Tamoxifen. Similarly, check with your doctor or pharmacist before taking any new medication while taking this one, to ensure that the combination is safe.

Tamoxifen may interact with the following preparations:

• Anti-steroid drugs(Aminoglutethimide)
• Estrogens or other hormone replacement therapy
• Breast cancer treatment(Anastrozole and Letrozole(Femara))
• Hyperprolactinemia(Bromocriptine)
• Anticonvulsants
• Chemotherapy medications
• Oral birth control pills
• Blood thinners(Warfarin)
• Antibiotics(rifabutin, rifampin , rifapentine)

Additional Information: DO NOT SHARE Tamoxifen with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.